Membrane trafficking and Annexin A6 group

GROUP PUBLICATIONS

GROUP PUBLICATIONS

Publications (last 5 years):

also in Pubmed.

 

Annexin A6-A multifunctional scaffold in cell motility.

Grewal T, Hoque M, Conway JR, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C.

Cell Adh Migr. 2017 Jan 6:1-17.

 
Annexin A6 in the liver: From the endocytic compartment to cellular physiology.
Enrich C, Rentero C, Grewal T.
Biochim Biophys Acta. 2017 Jun; 1864(6):933-946.
 

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.
Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC.
Redox Biol. 2017 Apr; 11:60-72.

Annexin A6 regulates adipocyte lipid storage and adiponectin release.

Krautbauer S, Haberl EM, Eisinger K, Pohl R, Rein-Fischboeck L, Rentero C, Alvarez-Guaita A, Enrich C, Grewal T, Buechler C, Neumeier M.
Mol Cell Endocrinol. 2017 Jan 5; 439:419-430.

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba
D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F.
Nat Commun. 2016 Nov 24; 7:13588.
 

Annexins - insights from knockout mice.
Grewal T, Wason SJ, Enrich C, Rentero C.
Biol Chem. 2016 Oct 1; 397(10):1031-53.
 

Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells.
Tran J, Magenau A, Rodriguez M, Rentero C, Royo T, Enrich C, Thomas SR, Grewal T, Gaus K.
PLoS One. 2016 Mar 15; 11(3):e0151556.
 

Annexin A6 regulates interleukin-2-mediated T-cell proliferation.

Cornely R, Pollock AH, Rentero C, Norris SE, Alvarez-Guaita A, Grewal T, Mitchell T, Enrich C, Moss SE, Parton RG, Rossy J, Gaus K.
Immunol Cell Biol. 2016 Jul; 94(6):543-53.
 

Hepatic Primary and Secondary Cholesterol Deposition and Damage in Niemann-Pick Disease.
Bosch M, Fajardo A, Alcalá-Vida R, Fernández-Vidal A, Tebar F, Enrich C, Cardellach F, Pérez-Navarro E, Pol A.
Am J Pathol. 2016 Mar; 186(3):517-23.
 

Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.
García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, Tebar F, Murray RZ, Timpson P, Enrich C, Grewal T, Rentero C.
J Biol Chem. 2016 Jan 15; 291(3):1320-35.
 

The cross-talk of LDL-cholesterol with cell motility: insights from the Niemann Pick Type C1 mutation and altered integrin trafficking.
Hoque M, Rentero C, Conway JR, Murray RZ, Timpson P, Enrich C, Grewal T.
Cell Adh Migr. 2015; 9(5):384-91.
 
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Rupérez C, Fernández-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A.
Nat Commun. 2015 May 27; 6:7176.
 
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.
Reales E, Bernabé-Rubio M, Casares-Arias J, Rentero C, Fernández-Barrera J, Rangel L, Correas I, Enrich C, Andrés G, Alonso MA.
J Cell Sci. 2015 Jun 15; 128(12):2261-70.
 
Role of cholesterol in SNARE-mediated trafficking on intracellular membranes.
Enrich C, Rentero C, Hierro A, Grewal T.
J Cell Sci. 2015 Mar 15; 128(6):1071-81.
 
Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains.
Alvarez-Guaita A, Vilà de Muga S, Owen DM, Williamson D, Magenau A, García-Melero A, Reverter M, Hoque M, Cairns R, Cornely R, Tebar F, Grewal T, Gaus K, Ayala-Sanmartín J, Enrich C, Rentero C.
Br J Pharmacol. 2015 Apr; 172(7):1677-90.

 

Cholesterol regaulates syntaxin 6 trafficking at the TGN/endosomal boundaries.

Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M.,Vilà de Muga, S., Alvarez-Guaita, A., Conway, J.R.W., Wood, P., Cairns, R., Lykopoulou, L., Grinberg, D., Vilageliu, L., Bosch, M., Heeren, J., Timpson, P., Pol, A., Tebar, F., Murray, R.Z., Grewal, T. and Enrich, C.

Cell Reports. 2014 May 8; 7(3):883-97.

 

Dynamics of KRas on endosomes:involvement of acidic phospholipids in its association.

Gelabert-Baldrich, M., Soriano-Castell, D., Calvo, M., Lu, A., Viña-Vilaseca, A., Rentero, C., Pol, A., Grinstein, S., Enrich, C. and Tebar, F.

FASEB J. 2014 Jul; 28(7):3023-37. 

 

The biliary epithelium gives rise to liver progenitor cells.

Rodrigo-Torres, D., Affò, S., Coll, M., Morales-Ibanez, O., Millán, C., Blaya, D., Alvarez-Guaita, A., Rentero, C., Arroyo, V., Caballerís J., van Grunsven, L.A., Enrich, C., Ginès, P., Bataller, R. and Sancho-Bru, P.

Hepatology. 2014 Oct; 60(4):1367-77.

 

Annexins - Scaffolds modulating PKC localization and signaling. 

Hoque M, Rentero C, Cairns R, Tebar F, Enrich C, Grewal T.

Cell Signal. 2014 Feb 27; 26(6):1213-1225. Review.

 

Annexins and endosomal signaling.

Tebar F, Gelabert-Baldrich M, Hoque M, Cairns R, Rentero C, Pol A, Grewal T, Enrich C.

Methods Enzymol. 2014;535:55-74. doi: 10.1016/B978-0-12-397925-4.00004-3.

 

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

Kassan A, Herms A, Fernández-Vidal A, Bosch M, Schieber NL, Reddy BJ, Fajardo A, Gelabert-Baldrich M, Tebar F, Enrich C, Gross SP, Parton RG, Pol A.

J Cell Biol. 2013 Dec 23; 203(6):985-1001.

 

Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity.

Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, Alvarez-Guaita A, Fernández-Rojo MA, Rentero C, Tebar F, Enrich C, Geli MI, Parton RG, Gross SP, Pol A.

Curr Biol. 2013 Aug 5; 23(15):1489-96.

 

Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.

Mulay V, Wood P, Manetsch M, Darabi M, Cairns R, Hoque M, Chan KC, Reverter M, Alvarez-Guaita A, Rye KA, Rentero C, Heeren J, Enrich C, Grewal T.

PLoS One. 2013 Apr 25; 8(4):e62667. 

 

Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex.

Duran JM, Campelo F, van Galen J, Sachsenheimer T, Sot J, Egorov MV, Rentero C, Enrich C, Polishchuk RS, Goñi FM, Brügger B, Wieland F, Malhotra V.

EMBO J. 2012 Dec 12; 31(24):4535-46. 

 

Annexin A6 is a scaffold for PKCα to promote EGFR inactivation.

Koese M, Rentero C, Kota BP, Hoque M, Cairns R, Wood P, Vilà de Muga S, Reverter M, Alvarez-Guaita A, Monastyrskaya K, Hughes WE, Swarbrick A, Tebar F, Daly RJ, Enrich C, Grewal T.

Oncogene. 2013 Jun 6; 32(23):2858-72.

 

A palmitoylation switch mechanism regulates Rac1 function and membrane organization.

Navarro-Lérida I, Sánchez-Perales S, Calvo M, Rentero C, Zheng Y, Enrich C, Del Pozo MA.

EMBO J. 2012 Feb 1; 31(3):534-51. doi: 10.1038/emboj.2011.446. Epub 2011 Dec 9.

 

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration.

Fernández-Rojo MA, Restall C, Ferguson C, Martel N, Martin S, Bosch M, Kassan A, Leong GM, Martin SD, McGee SL, Muscat GE, Anderson RL, Enrich C, Pol A, Parton RG.

Hepatology. 2012 May; 55(5):1574-84.

 

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function.

Reverter M, Rentero C, de Muga SV, Alvarez-Guaita A, Mulay V, Cairns R, Wood P, Monastyrskaya K, Pol A, Tebar F, Blasi J, Grewal T, Enrich C.

Mol Biol Cell. 2011 Nov; 22(21):4108-23. 

 

Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling.

Cornely R, Rentero C, Enrich C, Grewal T, Gaus K.

IUBMB Life. 2011 Nov; 63(11):1009-17. Review.

 

Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.

Vidal-Quadras M, Gelabert-Baldrich M, Soriano-Castell D, Lladó A, Rentero C, Calvo M, Pol A, Enrich C, Tebar F.

Traffic. 2011 Dec; 12(12):1879-96. 

 

Differential Regulation of RasGAPs in Cancer.

Grewal T, Koese M, Tebar F, Enrich C.

Genes Cancer. 2011 Mar; 2(3):288-97.

 

RAS/MAPK signalling modulates protein stability and cell surface expression of SR-BI.

Wood P, Mulay V, Darabi M, Chan KC, Heeren J, Pol A, Lambert G, Rye KA, Enrich C, Grewal T.

J Biol Chem. 2011 Jul 1; 286(26):23077-92.

 

Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility.

Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, Giralt A, Colell A, Balgoma D, Barbero E, González-Moreno E, Matias N, Tebar F, Balsinde J, Camps M, Enrich C, Gross SP, García-Ruiz C, Pérez-Navarro E, Fernández-Checa JC, Pol A.

Curr Biol. 2011 Apr 26; 21(8):681-6.

 

Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport.

Mulay V, Wood P, Rentero C, Enrich C, Grewal T.

Curr Pharm Biotechnol. 2011 Apr 6.

 

MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.

Aranda JF, Reglero-Real N, Kremer L, Marcos-Ramiro B, Ruiz-Sáenz A, Calvo M, Enrich C, Correas I, Millán J, Alonso MA.

Mol Biol Cell. 2011 Apr; 22(8):1252-62.

 

Annexin A6-Linking Ca(2+) signaling with cholesterol transport.

Enrich C, Rentero C, de Muga SV, Reverter M, Mulay V, Wood P, Koese M, Grewal T.

Biochim Biophys Acta. 2011 May; 1813(5):935-47.

 

Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes.

Woudenberg J, Rembacz KP, van den Heuvel FA, Woudenberg-Vrenken TE, Buist-Homan M, Geuken M, Hoekstra M, Deelman LE, Enrich C, Henning RH, Moshage H, Faber KN.

Hepatology. 2010 May; 51(5):1744-53.

 

Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis.

Grewal T, Koese M, Rentero C, Enrich C.

Int J Biochem Cell Biol. 2010 May; 42(5):580-4.

 

GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.

Lluis JM, Llacuna L, von Montfort C, Bárcena C, Enrich C, Morales A, Fernandez-Checa JC.

PLoS One. 2009 Nov 26; 4(11):e8059.

 

Hydrophobic and basic domains target proteins to lipid droplets.

Ingelmo-Torres M, González-Moreno E, Kassan A, Hanzal-Bayer M, Tebar F, Herms A, Grewal T, Hancock JF, Enrich C, Bosch M, Gross SP, Parton RG, Pol A.

Traffic. 2009 Dec; 10(12):1785-801.

 

Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling.

Moretó J, Vidal-Quadras M, Pol A, Santos E, Grewal T, Enrich C, Tebar F.

Cell Signal. 2009 Dec;21(12):1827-36. Epub 2009 Aug 8.

 

Annexins--modulators of EGF receptor signalling and trafficking.

Grewal T, Enrich C.

Cell Signal. 2009 Jun;21(6):847-58. Review.

 

Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro.

Stogbauer F, Weigert J, Neumeier M, Wanninger J, Sporrer D, Weber M, Schaffler A, Enrich C, Wood P, Grewal T, Aslanidis C, Buechler C.

Exp Mol Med. 2009 Jul 31;41(7):501-7.

 

Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane.

Ingelmo-Torres M, Gaus K, Herms A, González-Moreno E, Kassan A, Bosch M, Grewal T, Tebar F, Enrich C, Pol A.

Biochem J. 2009 May 27;420(3):373-81.

 

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes.

Lu A, Tebar F, Alvarez-Moya B, López-Alcalá C, Calvo M, Enrich C, Agell N, Nakamura T, Matsuda M, Bachs O.

J Cell Biol. 2009 Mar 23;184(6):863-79. Epub 2009 Mar 16.

 

Annexin A6 inhibits Ras signalling in breast cancer cells.

Vilá de Muga S, Timpson P, Cubells L, Evans R, Hayes TE, Rentero C, Hegemann A, Reverter M, Leschner J, Pol A, Tebar F, Daly RJ, Enrich C, Grewal T.

Oncogene. 2009 Jan 22;28(3):363-77. Epub 2008 Oct 13.

 

Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function.

Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen PC, Heeren J.

Bone. 2008 Aug;43(2):230-7. Epub 2008 Apr 10.

 

Calmodulin modulates H-Ras mediated Raf-1 activation.

Moretó J, Lladó A, Vidal-Quadras M, Calvo M, Pol A, Enrich C, Tebar F.

Cell Signal. 2008 Jun;20(6):1092-103. Epub 2008 Feb 5.

 

Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi.

Cubells L, Vilà de Muga S, Tebar F, Bonventre JV, Balsinde J, Pol A, Grewal T, Enrich C.

J Biol Chem. 2008 Apr 11;283(15):10174-83. Epub 2008 Feb 1.

 

Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin.

Lladó A, Timpson P, Vilà de Muga S, Moretó J, Pol A, Grewal T, Daly RJ, Enrich C, Tebar F.

Mol Biol Cell. 2008 Jan;19(1):17-29. Epub 2007 Oct 24.

 

Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.

Cubells L, Vilà de Muga S, Tebar F, Wood P, Evans R, Ingelmo-Torres M, Calvo M, Gaus K, Pol A, Grewal T, Enrich C.

Traffic. 2007 Nov;8(11):1568-89. Epub 2007 Sep 6.

 

Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation.

Sengupta P, Ruano MJ, Tebar F, Golebiewska U, Zaitseva I, Enrich C, McLaughlin S, Villalobo A.

J Biol Chem. 2007 Mar 16;282(11):8474-86. Epub 2007 Jan 16.

 

 

Carles Rentero

Publications (5 years):

 

1. Quantitative imaging of membrane lipid order in cells and organisms

Owen DM, Rentero C, Magenau A, Abu-Siniyeh A, Gaus K.

Nature Protocols. 2012. 7:24-35.

 

2. A palmitoylation switch mechanism regulates Rac1 function and membrane organization.

Navarro-Lérida I, Sánchez-Perales S, Calvo M, Rentero C, Zheng Y, Enrich C, Del Pozo MA.

EMBO Journal. 2011.

 

3. Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling.

Cornely R, Rentero C, Enrich C, Grewal T, Gaus K.

IUBMB Life. 2011. 63:1009-1017.

 

4. Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly and function

Reverter M, Rentero C, Vilà de Muga S, Alvarez-Guaita A, Mulay V, Cairns R, Wood P, Monastyrskaya K, Pol A, Tebar F, Blasi J, Grewal T, Enrich C

Molecular Biology of the Cell. 2011. 22:4108-4123.

 

5. Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis

Vidal-Quadras M, Gelabert-Baldrich M, Soriano-Castell D, Lladó A, Rentero C, Calvo M, Pol A, Enrich C, Tebar F.

Traffic. 2011. 12:1879-1896.

 

6. Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.

Le Lay S, Rodriguez M, Jessup W, Rentero C, Li Q, Cartland S, Grewal T, Gaus K

PLoS ONE. 2011. 6:e23353

 

7. Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis.

Römer W, Pontani LL, Sorre B, Rentero C, Berland L, Chambon V, Lamaze C, Bassereau P, Sykes C, Gaus K, Johannes L.

Cell. 2010 Feb 19;140(4):540-53.

 

8. PALM imaging and cluster analysis of protein heterogeneity at the cell surface.

Owen DM, Rentero C, Rossy J, Magenau A, Williamson D, Rodriguez M, Gaus K.

J Biophotonics. 2010 Jul;3(7):446-54.

 

9. Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases.

Lu HK, Rentero C, Raftery MJ, Borges L, Bryant K, Tedla N.

J Biol Chem. 2009 Dec 11;284(50):34839-48. Epub 2009 Oct 15.

 

10. Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway.

Kockx M, Guo DL, Traini M, Gaus K, Kay J, Wimmer-Kleikamp S, Rentero C, Burnett JR, Le Goff W, Van Eck M, Stow JL, Jessup W, Kritharides L.

J Biol Chem. 2009 Sep 4;284(36):24144-54. Epub 2009 Jul 9.

 

11. Quantitative microscopy: protein dynamics and membrane organisation.

Owen DM, Williamson D, Rentero C, Gaus K.

Traffic. 2009 Aug;10(8):962-71. Epub 2009 Apr 4. Review.

 

12. Caveolin-1-dependent and -independent membrane domains.

Le Lay S, Li Q, Proschogo N, Rodriguez M, Gunaratnam K, Cartland S, Rentero C, Jessup W, Mitchell T, Gaus K.

J Lipid Res. 2009 Aug;50(8):1609-20. Epub 2008 Dec 12.

 

13. LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma.

Mitchell A, Rentero C, Endoh Y, Hsu K, Gaus K, Geczy C, McNeil HP, Borges L, Tedla N.

Eur J Immunol. 2008 Dec;38(12):3459-73.

 

14. Functional implications of plasma membrane condensation for T cell activation.

Rentero C, Zech T, Quinn CM, Engelhardt K, Williamson D, Grewal T, Jessup W, Harder T, Gaus K.

PLoS ONE. 2008 May 28;3(5):e2262.

 

 

Teresa Royo

Publications (most relevant):

 

1. Adipocyte differentiation-related protein is induced by LRP1-mediated aggregated LDL internalization in human vascular smooth muscle cells and macrophages.

Llorente-Cortés V, Royo T, Juan-Babot O, Badimon L.

J Lipid Res. 2007 Oct;48(10):2133-40. Epub 2007 Jul 9.

 

 2. Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages.

Llorente-Cortés V, Royo T, Otero-Viñas M, Berrozpe M, Badimon L.

Cardiovasc Res. 2007 Jun 1;74(3):526-36. Epub 2007 Feb 21.

 

3. Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel-Palade bodies and in human endothelial cells.

Royo T, Martínez-González J, Vilahur G, Badimon L.

Atherosclerosis. 2003 Mar;167(1):55-63.

 

4. Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia.

Royo T, Alfón J, Berrozpe M, Badimon L.

Eur J Clin Invest. 2000 Oct;30(10):843-52. 

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