EGFR and Calmodulin Signalling group



1- Vidal-Quadras M, Gelabert-Baldrich M, Soriano-Castell D, Lladó A, Rentero C, Calvo M, Pol A, Enrich C and Tebar F. Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.Traffic (2011) 12: 1879-96.


2- Reverter M, Rentero C, de Muga SV, Alvarez-Guaita A, Mulay V, Cairns R, Wood P, Monastyrskaya K, Pol A, Tebar F, Blasi J, Grewal T and Enrich C. Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and functionMol. Biol. Cell. (2011) 22: 4108-23.


3- Grewal T, Koese M, Tebar F and Enrich C. Differential Regulation of RasGAPs in CancerGenes and Cancer (2011) 2:288-97.


4- Alvarez-Moya B, Barceló C, Tebar F, Jaumot M and Agell N. CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators. Small Gtpases (2011) 2: 99-103.


5- Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, Giralt A, Colell A, Balgoma D, Barbero E, González-Moreno E, Matias N, Tebar F, Balsinde J, Camps M, Enrich C, Gross SP, García-Ruiz C, Pérez-Navarro E, Fernández-Checa JC and Pol A. Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol. (2011) 21(8): 681-6.


6- Ingelmo-Torres, M, Graus, K, Herms, A, González-Moreno, E, Kassan, A, Bosch, M, Grewal, T, Tebar, F, Enrich, C and Pol, A. Triton X-100 promotes a choleserol-dependent condensation of the plasma membraneBiochem. J. (2009) 420: 373-381.


7- Ingelmo-Torres, M, González-Moreno, E, Kassan, A, Hanzal-Bayer, M,  Tebar, F, Herms, A, Grewal, T, Hancock, JF, Enrich, C, Mosch, M, Gross, SP, Parton, RG and Pol, A. Hydrophobic and basic domains target protein to lipid dropletsTraffic (2009) 10: 1785-1801.


8- Moretó J, Vidal-Quadras M, Pol A, Santos E, Grewal T, Enrich C, Tebar F. Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signalingCell Signal. (2009) 21(12):1827-36.


9- Lu A, Tebar F, Alvarez-Moya B, López-Alcalá C, Calvo M, Enrich C, Agell N, Nakamura T, Matsuda M, Bachs O. A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J. Cell. Biol. (2009) 184: 863-879.


10- Vilà de Muga S, Timpson P, Cubells L, Evans R, Hayes TE, Rentero C, Hegemann A, Reverter M, Leschner L, Pol A, Tebar F, Daly RJ, Enrich C and Grewal T. Annexin A6 inhibits Ras signalling in breast cancer cellsOncogene. (2009) 22:363-377.


11- Moretó J, Lladó A, Vidal-Quadras M, Calvo M, Pol A, Enrich C and Tebar F. Calmodulin modulates H-Ras mediated Raf-1 activationCell. Signal. (2008) 20: 1092-1103


12- Lladó A, Timpson P, Vilà de Muga A, Moretó J, Pol A, Grewal T, Daly RJ, Enrich C and Tebar F. Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactinMol. Biol. Cell (2008) 19: 17-29.


13- Cubells L, Vilà de Muga S, Tebar F, Pol A, Grewal T and Enrich C. Annexin A6-induced inhibition of cPLA2 is linked to cav-1 export from the GolgiJ. Biol. Chem. (2008) 283, 10174-10183      .


14- Cubells L, Vila de Muga S A, Tebar F, Wood P, Evans R, Ingelmo-Torres M, Calvo M, Gaus K, Pol A, Grewal T and Enrich C. Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complexTraffic (2007) 8, 1568-1589.


15- Sengupta P, Ruano MJ, Tebar F, Golebiewska U, Zaitseva I, Enrich C, McLaughlin S and Villalobo A. Membrane-permeable calmodulin inhibitors (e.g., W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on EGFR activation.  J. Biol. Chem. (2007) 282, 8474-8486.               


16- Fernandez MA, Albor CV, Ingelmo-Torres M, Nixon SJ, Ferguson C, Kurzschalia T, Tebar F, Enrich C, Parton RG and Pol A. Caveolin-1 is essential for liver regenerationScience (2006) 313, 1628- 1632.


17- Turro S, Ingelmo-Torres M, Estanyol JM, Tebar F, Fernandez MA, Albor CV, Gaus K, Grewal T, Enrich C and Pol A. Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid DropletsTraffic (2006) 7, 1254-1269.


18- Fernández E, Jiménez-Vidal M, Calvo M, Zorzano A, Tebar F, Palacín M and Chillarón, J. The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the HATsJ. Biol. Chem.  (2006) 281, 26552- 26561.


19- Grewal T, Tebar F, Pol A and Enrich C. Involvement of targeting and scaffolding proteins in the regulation of the EGFR/Ras/MAPK pathway in oncogenesisCurrent Signal Transduction Therapy (2006).


20- Rentero C, Evans R, Wood P, Tebar F, Vila de Muga S, Cubells L, de Diego I, Hayes TE, Hughes WE, Pol A, Rye KA, Enrich C and Grewal T. Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells. Cell Signal. (2006) 18, 1006-1016.


21- Grewal T, Evans R, Rentero C, Tebar F, Cubells L, de Diego I, Kirchhoff MF, Hughes WE, Heeren J, Rye KA, Rinninger F, Daly RJ, Pol A and Enrich C. Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activityOncogene (2005) 24, 5809-20.


22- Lladó A*, Tebar F*, Calvo M, Moretó J, Sorkin A and  Enrich C (* Both authors contributed equally to this work). Protein kinase C-d - calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomesMol. Biol. Cell (2004) 11, 4877-4891.


23- Grewal T, Tebar F, Pol A and Enrich C. Annexin 6 and its role in Ras signallingAnnexins (2004) 1, 62-67.


24- Buira I, Poch E, Sánchez O, Fernández-Varo G, Grau M, Tebar F, Ramírez I and Soley M. Sialoadenectomy alters liver cell turn-over and function in miceJ. Cell. Physiology. (2004) 198, 12-21.


25- Grewal T, De Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F and Enrich C. HDL-induced signaling of MAPK pathway involves SR-B1-mediated activation of RasJ. Biol. Chem. (2003) 278, 16478-16481.


26- Tebar F, Villalonga P, Sorkina T, Agell N, Sorkin A and Enrich C. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathwayMol. Biol. Cell (2002) 13, 2057-2068. 


27- Tebar F, Lladó A and Enrich C. Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKCFebs Letters. (2002) 517, 206-210.

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