Membrane trafficking and Annexin A6 group

RESEARCH INTERESTS

Our group is interested on the molecular basis of membrane traffic in mammalian cells. This basic research is important for the understanding of a number of diseases including cancer, diabetes, and heart disease or in liver disorders.


We study the regulation of a variety of aspects of protein and cholesterol trafficking and signal transduction in the endocytic compartment, a sorting and processing station for proteins internalized by cells, as well as along the post-Golgi secretory pathway.

 

Our longest running project concerns an analysis of membrane trafficking along the endocytic pathway and in particular to study the role of a member of the annexin family, Annexin A6 (AnxA6). Annexins are an evolutionarily conserved multigene family with roles in vesicle trafficking, phospholipid metabolism, actin dynamics, apoptosis and cell transformation.

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