Membrane trafficking and Annexin A6 group


Our group is interested on the molecular basis of membrane traffic in mammalian cells. This basic research is important for the understanding of a number of diseases including cancer, diabetes, and heart disease or in liver disorders.

We study the regulation of a variety of aspects of protein and cholesterol trafficking and signal transduction in the endocytic compartment, a sorting and processing station for proteins internalized by cells, as well as along the post-Golgi secretory pathway.


Our longest running project concerns an analysis of membrane trafficking along the endocytic pathway and in particular to study the role of a member of the annexin family, Annexin A6 (AnxA6). Annexins are an evolutionarily conserved multigene family with roles in vesicle trafficking, phospholipid metabolism, actin dynamics, apoptosis and cell transformation.

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