Grup de tràfic de lípids i malaties relacionades

Publicacions del grup

Publicacions del grup



1 - AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.

Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Ruperez C, Fernandez-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A.

Nature Communications 2015 May 27; 6:7176.

F1000 recommended:


2 - Biogenesis of the Multifunctional Lipid Droplet: Lipids, Proteins, and Sites.

Pol A, Gross SP, and Parton RG.

The Journal of Cell Biology 2014 Mar 3; 204(5):635-46.



3 - Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity.

Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, Alvarez-Guaita A, Fernández-Rojo MA, Rentero C, Tebar F, Enrich C, Geli MI, Parton RG, Gross SP, Pol A.

Current Biology 2013 Aug 5; 23(15):1489-96.

F1000 recommended:


4 - Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility.

Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, Giralt A, Colell A, Balgoma D, Barbero E, González-Moreno E, Matias N, Tebar F, Balsinde J, Camps M, Enrich C, Gross SP, García-Ruiz C, Pérez-Navarro E, Fernández-Checa JC, Pol A.

Current Biology 2011 Apr 26; 21(8):681-6.

Editor’s choice in Science:


5 - Caveolin-1 is essential for liver regeneration.

Fernández M, Albor C, Ingelmo M, Nixon S, Ferguson C, Kurzchalia T, Tebar F, Enrich C, Parton RG, Pol A.

Science 2006 Sep 15; 313(5793):1628-32.

Editor’s choice in Science:

Highlighted in Science:

F1000 recommended:


6 - A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance.

Pol A, Luetterforst R, Lindsay M, Heino S, Ikonen E, Parton RG.

The Journal of Cell Biology 2001 Mar 5; 152(5):1057-70.

Highlighted in Nature Reviews:

Highlighted in J Cell Biol:



63 - Soriano-Castell D, Chavero A, Rentero C, Bosch M, Vidal-Quadras M, Pol A, Enrich C, Tebar F.

ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis.

Sci Rep. 2017 Jul 31;7(1):6866. Research Article.


62 -  Fleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G, Lopez-Iglesias C, Bosch M, Pol A, Brönstrup M, Diez J, Meyerhans A.

The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). Research Article.


*61 - Sala-Vila A, Navarro-Lérida I, Bosch M, Calvo C, López JA, Calvo E, Ferguson C, Balsinde J, Enríquez JA, Giacomello M, Scorrano L, Parton RG, Vázquez J, Pol A*, del Pozo MA*.

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice.

Sci Rep. 2016. Jun 6;6:27351. Research Article.


*60 - Bosch, M., A. Fajardo, R. Alcala-Vida, A. Fernandez-Vidal, F. Tebar, C. Enrich, F. Cardellach, E. Perez-Navarro, and A. Pol.

Hepatic Primary and Secondary Cholesterol Deposition and Damage in Niemann-Pick Disease.

Am J Pathol. 2016 Jan 16. pii: S0002-9440(15)00693-8. Research Article.


59 - Garcia-Melero, A., Reverter, M., Hoque, M., Meneses-Salas, E., Koese, M., Conway, J. R., Johnsen, C. H., Alvarez-Guaita, A., Morales-Paytuvi, F., Elmaghrabi, Y. A., Pol, A., Tebar, F., Murray, R. Z., Timpson, P., Enrich, C., Grewal, T., and Rentero, C.

Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.

J Biol Chem. 2016 Jan 15;291(3):1320-35. Research Article.


*58 - Herms, A., M. Bosch, B.J. Reddy, N.L. Schieber, A. Fajardo, C. Ruperez, A. Fernandez-Vidal, C. Ferguson, C. Rentero, F. Tebar, C. Enrich, R.G. Parton, S.P. Gross, and A. Pol.

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.

Nat Commun. 2015 May 27;6:7176.


57 - Gelabert-Baldrich M, Soriano-Castell D, Calvo M, Lu A, Viña A, Rentero C, Pol A, Grinstein S, Enrich C, Tebar F.

Dynamics of KRas on endosomes: Involvement of acidic phospholipids in its association.

FASEB J. 2014 Jul;28(7):3023-3037.Research Article.


56 - Reverter M, Rentero C, Garcia-Melero A, Hoque M, Vilà de Muga S, Alvarez-Guaita A, Conway J, Wood P, Cairns R, Lykopoulou L, Grinberg D, Vilageliu L, Bosch M, Heeren J, Blasi J, Timpson P, Pol A, Tebar F, Murray RZ, Grewal T, Enrich, C.

Cholesterol regulates Syntaxin 6 trafficking at the TGN-endosomal boundaries.

Cell Rep. 2014 May 8;7(3):883-97.Review article.


*55 - Pol A, Gross SP, and Parton RG.

The Biogenesis of the Multifunctional Lipid Droplet: Lipids, Proteins, and Sites.

J Cell Biol. 2014 March 3; 204(5). Review Article.


54 - Tebar F, Gelabert-Baldrich M, Hoque M, Cairns R, Rentero C, Pol A, Grewal T, Enrich C.

Annexins and endosomal signaling.

Methods Enzymol. 2014;535:55-74. Research Article.


*53 - Kassan A, Herms A, Fernández-Vidal A, Bosch M, Schieber NL, Reddy BJ, Fajardo A, Gelabert-Baldrich M, Tebar F, Enrich C, Gross SP, Parton RG, Pol A.

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

J Cell Biol. 2013 Dec 23;203(6):985-1001. Research Article.


*52 - Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, Alvarez-Guaita A, Fernández-Rojo MA, Rentero C, Tebar F, Enrich C, Geli MI, Parton RG, Gross SP, Pol A.

Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity.

Curr Biol. 2013 Aug 5;23(15):1489-96. Research Article.


51 - Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP.

A novel role for lipid droplets in the organismal antibacterial response.

Elife. 2012;1:e00003. doi: 10.7554/eLife.00003. Research Article.


50 - Fernandez-Rojo MA, Restall C, Ferguson C, Martel N, Martin S, Bosch M, Kassan A, Leong GM, Martin SD, McGee SL, Muscat GE, Anderson RL, Enrich C, Pol A, Parton RG.

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration.

Hepatology. 2012 May; 55:1574-84. Research Article.


49 - Vidal-Quadras M, Gelabert-Baldrich M, Soriano-Castell D, Lladó A, Rentero C, Calvo M, Pol A, Enrich C, Tebar F.

Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.

Traffic. 2011 Dec;12(12):1879-96. Research Article.


*48 - Bosch M, Marí M, Gross SP, Fernández-Checa JC, Pol A.

Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease.

Traffic. 2011 Nov;12(11):1483-9. Research Article.


47 - Reverter M, Rentero C, de Muga SV, Alvarez-Guaita A, Mulay V, Cairns R, Wood P, Monastyrskaya K, Pol A, Tebar F, Blasi J, Grewal T, Enrich C.

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function.

Mol Biol Cell. 2011 Nov;22(21):4108-23. Research Article.


46 - Astudillo AM, Pérez-Chacón G, Meana C, Balgoma D, Pol A, Del Pozo MA, Balboa MA, Balsinde J.

Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to reduced eicosanoid synthesis.

J Biol Chem. 2011 Oct 7;286(40):35299-307. Research Article.


45 - Wood P, Mulay V, Darabi M, Chan K, Heeren J, Pol A, Lambert G, Rye K, Enrich C, Grewal T.

Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.

J Biol Chem. 2011 Jul 1;286(26):23077-92. Research Article.


*44 - Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, Giralt A, Colell A, Balgoma D, Barbero E, González-Moreno E, Matias N, Tebar F, Balsinde J, Camps M, Enrich C, Gross SP, García-Ruiz C, Pérez-Navarro E, Fernández-Checa JC, Pol A.

Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility.

Curr Biol. 2011 Apr 26;21(8):681-6. Research Article.


43 - del Toro D, Xifró X, Pol A, Humbert S, Saudou F, Canals JM, Alberch J.

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

J Neurochem. 2010 Oct;115(1):153-67. Research Article.


*42 - Ingelmo-Torres, M., E. Gonzalez-Moreno, A. Kassan, M. Hanzal-Bayer, F. Tebar, A. Herms, T. Grewal, J.F. Hancock, C. Enrich, M. Bosch, S.P. Gross, R.G. Parton, Pol A.

Hydrophobic and basic domains target proteins to lipid droplets.

Traffic. 2009 Dec 10:1785-801. Research Article.


*41 - Ingelmo-Torres M, Gaus K, Herms A, González-Moreno E, Kassan A, Bosch M, Grewal T, Tebar F, Enrich C, Pol A.

Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane.

Biochem J. 2009 May 27;420(3):373-81. Research Article.


40 - Moreto J, Vidal-Quadras M, Pol A, Santos E, Grewal T, Enrich C, Tebar F.

Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling

Cell Signal. 2009 Dec 21;12:1827-1836. Research Article.


39 - Vilá de Muga S, Timpson P, Cubells L, Evans R, Hayes TE, Rentero C, Hegemann A, Reverter M, Leschner J, Pol A, Tebar F, Daly RJ, Enrich C, Grewal T.

Annexin A6 inhibits Ras signalling in breast cancer cells

Oncogene. 2009 Jan 22;28(3):363-77. Research Article.


*38 - Domingo-Domènech J, Pippa R, Tápia M, Gascón P, Bachs O, Bosch M.

Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells.

Breast Cancer Res Treat. 2008 Nov;112(1):53-62. Research Article.


37 - Moretó J, Lladó A, Vidal-Quadras M, Calvo M, Pol A, Enrich C, Tebar F.

Calmodulin modulates H-Ras mediated Raf-1 activation

Cell Signal. 2008 Jun;20(6):1092-103. Research Article.


36 - Syriani E, Gomez-Cabrero A, Bosch M, Moya A, Abad E, Gual A, Gasull X, Morales M.

Profilin induces lamellipodia by growth factor-independent mechanism.

FASEB J. 2008 May;22(5):1581-96. Research Article.


35 - Cubells L, de Muga SV, Tebar F, Bonventre JV, Balsinde J, Pol A, Grewal T, Enrich C.

Annexin A6-induced inhibition of cytoplasmic phospholipase A(2) is linked to caveolin-1 export from the Golgi

J Biol Chem. 2008 Apr 11;283(15):10174-83. Research Article.


34 - Llado A, Timpson P, Vila S, Moreto J, Pol A, Grewal T, Daly R, Enrich C, Tebar F.

PKC and Calmodulin Regulate EGF Receptor Recycling from Early Endosomes through Arp2/3 Complex and Cortactin.

Mol Biol Cell. 2007 Oct 24. Research Article.


33 - Cubells L, Vila de Muga S, Tebar F, Wood P, Evans R, Ingelmo-Torres M, Calvo M, Gaus K, Pol A, Grewal T, Enrich C.

Annexin A6-Induced Alterations in Cholesterol Transport and Caveolin Export from the Golgi Complex.

Traffic. 2007 Oct 15;8(11):1568-1589. Research Article.


32 - Tapia MA, González-Navarrete I, Dalmases A, Bosch M, Rodriguez-Fanjul V, Rolfe M, Ross JS, Mezquita J, Mezquita C, Bachs O, Gascón P, Rojo F, Perona R, Rovira A,

Albanell J.

Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin.

Cell Cycle. 2007 Sep 15;6(18):2284-92. Research Article.


31 - Rentero C, Evans R, Wood P, Tebar F, Vila de Muga S, Cubells L, de Diego I, Hayes TE, Hughes WE, Pol A, Rye KA, Enrich C, Grewal T.

Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells.

Cell Signal. 2006 Jul;18(7):1006-16. Research Article.


*30 - Fernández M, Albor C, Ingelmo-Torres M, Nixon S, Ferguson C, Kurzchalia T, Tebar F, Enrich C, Parton RG, Pol A.

Caveolin-1 is essential for liver regeneration.

Science. 2006 Sep 15;313(5793):1628-32. Research Article.


29 - Domingo-Domenech J, Oliva C, Rovira A, Codony-Servat J, Bosch M, Filella X, Montagut C, Tapia M, Campás C, Dang L, Rolfe M, Ross JS, Gascon P, Albanell J, Mellado B.

Interleukin6, anuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

Clin Cancer Res. 2006 Sep 15;12(18):5578-86. Research Article.


*28 - Turró S, Ingelmo-Torres M, Estanyol J, Tebar F, Fernández MA, Albor CV, Gaus K, Grewal T, Enrich C, Pol A.

Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid Droplets.

Traffic. 2006 Sep;7(9):1254-69. Research Article.


*27 - Enrich C, Pol A.

Lipid Rafts and Caveolae

Future Lipidology. 2006 Aug; 1(4):385-7. ( Book Review.


26 - Codony-Servat J, Tapia MA, Bosch M, Oliva C, Domingo-Domenech J, Mellado B, Rolfe M, Ross JS, Gascon P, Rovira A, Albanell J.

Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells.

Mol Cancer Ther. 2006 Mar;5(3):665-75. Research Article.


*25 - Pol A, Martin S, Fernández MA, Ingelmo-Torres M, Ferguson C, Enrich C, Parton RG.

Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies.

Mol Biol Cell. 2005 Apr;16(4):2091-105. Research Article.


24 - Grewal T, Evans R, Rentero C, Tebar F, Cubells L, de Diego I, Kirchhoff MF, Hughes WE, Heeren J, Rye KA, Rinninger F, Daly RJ, Pol A, Enrich C.

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity.

Oncogene. 2005 Sep 1;24(38):5809-20. Research Article.


*23 - Fernández MA, Turró S, Ingelmo-Torres M, Enrich C, Pol A.

Intracellular trafficking during liver regeneration. Alterations in late endocytic and transcytotic pathways.

J Hepatol. 2004 Jan; 40(1):132-9. Research Article.


*22 - Pol A, Martin S, Fernandez MA, Ferguson C, Carozzi A, Luetterforst R, Enrich C, Parton RG.

Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant.

Mol Biol Cell. 2004 Jan; 15(1):99-110. Research Article.


21 - Carozzi AJ, Roy S, Morrow IC, Pol A, Wyse B, Clyde-Smith J, Prior IA, Nixon SJ, Hancock JF, Parton RG.

Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3.

J Biol Chem. 2002 May 17;277(20):17944-9. Research Article.


20 - Villalonga P, López-Alcalá C, Bosch M, Chiloeches A, Rocamora N, Gil J, Marais R, Marshall CJ, Bachs O, Agell N.

Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.

Mol Cell Biol. 2001 Nov;21(21):7345-54. Research Article.


19 - Coleman M, Sahai E, Yeo M, Bosch M, Dewar A. Olson MF.

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCKI.

Nat Cell Biol. 2001 Apr1; 3(4): 339-345. Research Article.


*18 - Pol A, Luetterforst R, Lindsay M, Heino S, Ikonen E, Parton RG.

A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance.

J Cell Biol. 2001 Mar 5; 152(5):1057-70. Research Article.


*17 - Parreno M*, Pol A*, Cadefau J, Parra J, Alvarez L, Membrilla E, Cusso R.

(*These authors made equal contribution to this work)

Changes of skeletal muscle proteases activities during a chronic low-frequency stimulation period.

Pflugers Arch. 2001 Aug;442(5):745-51. Research Article.


*16 - Pol A, Lu A, Pons M, Peiro S, Enrich C.

Epidermal growth factor-mediated caveolin recruitment to early endosomes and MAPK activation. Role of cholesterol and actin cytoskeleton.

J Biol Chem. 2000 Sep 29; 275(39):30566-72. Research Article.


*15 - Pol A, Calvo M, Lu A, Enrich C.

EGF triggers caveolin redistribution from the plasma membrane to the early/sorting endocytic compartment of hepatocytes.

Cell Signal. 2000 Aug; 12(8):537-40. Research Article.


14 - Pons M, Ihrke G, Koch S, Biermer M, Pol A, Grewal T, Jackle S, Enrich C.

Late endocytic compartments are major sites of annexin VI localization in NRK fibroblasts and polarized WIF-B hepatoma cells.

Exp Cell Res. 2000 May 25;257(1):33-47. Research Article.


*13 - Calvo M*, Pol A *, Lu A, Ortega D, Pons M, Blasi J, Enrich C.

(*These authors made equal contribution to this work)

Cellubrevin is present in the basolateral endocytic compartment of hepatocytes and follows the transcytotic pathway after IgA internalization.

J Biol Chem. 2000 Mar 17;275(11):7910-7. Research Article.


12 - Enrich C, Pol A, Calvo M, Pons M, Jackle S.

Dissection of the multifunctional "Receptor-Recycling" endocytic compartment of hepatocytes.

Hepatology. 1999 Nov;30(5):1115-20. Review Article.


*11 - Pol A, Calvo M, Lu A, Enrich C.

The "early-sorting" endocytic compartment of rat hepatocytes is involved in the intracellular pathway of caveolin-1 (VIP-21).

Hepatology. 1999 Jun; 29(6):1848-57. Research Article.


10 - Babiá T, Ayala I, Valderrama F, Mato E, Bosch M, Santarén JF, Renau-Piqueras J, Kok JW, Thomson TM, Egea G.

N-Ras induces alterations in Golgi complex architecture and in constitutive protein transport.

J Cell Sci. 1999 Feb;112 ( Pt 4):477-89. Research Article.


*9 - Pol A, Calvo M, Enrich C.

Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment.

FEBS Lett. 1998 Dec 11; 441(1):34-8. Research Article.


*8 - Bosch M, Gil J, Bachs O, Agell N.

Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1).

J Biol Chem. 1998 Aug 21;273(34):22145-50. Research Article.


*7 - Ortega D*, Pol A *, Biermer M, Jackle S, Enrich C.

(*These authors made equal contribution to this work)

Annexin VI defines an apical endocytic compartment in rat liver hepatocytes.

J Cell Sci. 1998 Jan;111 ( Pt 2):261-9. Research Article.


*6 - Pol A, Enrich C.

Membrane transport in rat liver endocytic pathways: preparation, biochemical properties and functional roles of hepatic endosomes.

Electrophoresis. 1997 Dec;18(14):2548-57. Review Article.


*5 - Pol A, Ortega D, Enrich C.

Identification of cytoskeleton-associated proteins in isolated rat liver endosomes.

Biochem J. 1997 Nov 1;327 ( Pt 3):741-6. Research Article.


*4 - Pol A, Ortega D, Enrich C.

Identification and distribution of proteins in isolated endosomal fractions of rat liver: involvement in endocytosis, recycling and transcytosis.

Biochem J. 1997 Apr 15;323 ( Pt 2):435-43. Research Article.


3 - López-Girona A, Bosch M, Bachs O, Agell N.

Addition of calmodulin antagonists to NRK cells during G1 inhibits proliferating cell nuclear antigen expression.

Cell Calcium. 1995 Jul;18(1):30-40. Research Article.


*2 - Bosch M, López-Girona A, Bachs O, Agell N. Research Article.

Protein kinase C regulates calmodulin expression in NRK cells activated to proliferate from quiescence.

Cell Calcium. 1994 Dec;16(6):446-54. Research Article.


1 - Agell N, Pujol MJ, López-Girona A, Bosch M, Rosa JL, Bachs O.

Calmodulin expression during rat liver regeneration.

Hepatology. 1994 Oct;20(4 Pt 1):1002-8. Research Article.

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