20 years studying the regulation of membrane trafficking

During the last 20 years we studied the role and function of a variety of molecules involved in the regulation of membrane trafficking. Calmodulin, caveolin, annexin A6, cholesterol or the EGF-receptor have been used as paradigm to dissect the intracellular pathways and compartments in polarize and in non-polarized cells, as well as in animal models.

 

By means of electron and confocal microscopy, molecular biology, biochemistry, subcellular fractionation and a variety of state-of-the-art procedures we have dissected the endocytic compartment, revisited the lipid droplets and the endoplasmic reticulum, and examined the fine structure of membrane domains.

 

The aim is to understand how signals at the cell surface are transduced to trigger reactions leading to metabolic and proliferative outputs, and how defects in these mechanisms cause disease.

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